Klinik für Neurologie

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Collaborations:                                                                                           

Dr. Gunnar P.H. Dietz, Ph.D., H. Lundbeck A/S, Valby, Denmark, http://www.lundbeck.com/

Dr. Anders Brandt, Ph.D., Lundbeck A/S, Valby, Denmark, http://www.lundbeck.com/

Dr. rer. nat. Martin Hammer, Department of Experimental Ophthalmology, Universitätsklinikum Jena, Germany, http://egotec/augenklinik/Forschung/Exp_+Ophthalmologie.html

Dr. Yun-Zheng Le, Ph.D., Department of Medicine & Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, USA, http://w3.ouhsc.edu/Endocrinology/faculty/Le.asp

Dr. med. Alexandra Kretz, Research group Neuroregeneration, Hans-Berger Clinic of Neurology, Universitätsklinikum Jena, Germany, http://www.neuro.uniklinikum-jena.de/Forschung.htlm

Dr. Christiane Frahm, Research group Aging and plasticity, Hans-Berger Clinic of Neurology, Universitätsklinikum Jena, Germany, http://www.neuro.uniklinikum-jena.de/Forschung.htlm

Dr. Andrey Irintchev, Experimentelle HNO, Klinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Jena, Germany, http://www.hno.uniklinikum-jena.de/

 

Funding:

Deutsche Forschungsgemeinschaft (DFG) (SCHM2639/1-1)

Interdisziplinäres Zentrum für Klinische Forschung (IZKF)

 

Selected references

Wohl SG, Schmeer CW, Friese T, Witte OW, Isenmann S (2011) In Situ dividing and phagocytosing retinal microglia express nestin, vimentin, and NG2 in vivo. PLoS One 6:e22408.

Krempler K, Schmeer CW, Isenmann S, Witte OW, Lowel S (2011) Simvastatin improves retinal ganglion cell survival and spatial vision after acute retinal ischemia/reperfusion in mice. Investigative ophthalmology & visual science 52:2606-2618.

Wohl SG, Schmeer CW, Witte OW, Isenmann S (2010) Proliferative response of microglia and macrophages in the adult mouse eye after optic nerve lesion. Investigative ophthalmology & visual science 51:2686-2696.

Wohl SG, Schmeer CW, Kretz A, Witte OW, Isenmann S (2009) Optic nerve lesion increases cell proliferation and nestin expression in the adult mouse eye in vivo. Experimental neurology 219:175-186.

Schmeer C, Gamez A, Tausch S, Witte OW, Isenmann S. Statins modulate heat shock protein expression and enhance retinal ganglion cell survival after transient retinal ischemia/reperfusion in vivo. Invest Ophthalmol Vis Sci 2008:49;4971-81.

Schmeer C, Kretz A, Isenmann SL. Statin-mediated protective effects in the central nervous system: General mechanisms and putative role of stress proteins. Restor Neurol Neurosci 2006:24;79-95.

Schmeer C, Straten G, Kügler S, Gravel C, Bahr M, Isenmann S. Dose-dependent rescue of axotomized rat retinal ganglion cells by adenovirus-mediated expression of glial cell-line derived neurotrophic factor in vivo. Eur J Neurosci 2002:15;637-43.

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